I like the ideas, but regeneration would need to be more for endgame. Maybe 10 life or so.
I would also be interested in an absorb ability where you gain mana from spells cast (50% of spell cost) or a vaccine status that protects from negative statuses (either 1 status, or lasting a duration)
If we could have another offensive attack based one. I think a vampire status could be fun. Half your attack but next attack steals life instead. It would be a good way to keep 1st place alive longer