Yeah. For example, these have been my teams:
There was nothing I could swap for Valkyrie on the blue team to make it run as well as it did so eventually I stopped trying.
Further since those 2 are that good together, Khorvash returned the favor with Draakulis catching the extra blue. Void Portal just filled out the colors and won over Dragon Soul since he could summon and was Impervious (laughs at Kraken from the last spot).
All brown for today. Tried several variations before settling on this. Ragnagord got filled on 1 surged red, who'd fill Gorgotha and well you can see how it played out. Funny thing was Khorvash was killed off in fights 1 and 2 stupidly fast (Amira and Death Mark) but he lived up to expectations in the later fights.
Yellow is next and I'm back to 3. Mercy is once again the odd one out but like blue, nothing works better to fill her spot. Purple will be 4 as I just really have fun with the lark I threw together. Green, no clue as I dislike everything I've thought of and of course that's when we face Santa's so the opponents will be overpowered too.
So yeah, by going with 3 at worse, I have far less stress and a stronger team to win. 5000+ is still great for the team.