Spell, Mana Cost and traits, everything in Famine screams for a nerf.
I do have famine fully traited, playing him is no fun, playing against him is no fun.
An interesting way to nerf him would be to (finally) bring some Mana Drain Immunity. Also consider (not for famine in particular) : true damage immunity and stat reduction / stat theft immunity. And, by all mean, do not fit them all together in impervious.